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KMID : 0892920150240010071
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Experimental Neurobiology
2015 Volume.24 No. 1 p.71 ~ p.83
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Long-term Treatment with Oriental Medicinal Herb Artemisia princeps Alters Neuroplasticity in a Rat Model of Ovarian Hormone Deficiency
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Kim Hyun-Bum
Kwon Byeong-Jae
Cho Hyun-Ji
Kim Ji-Won
Chon Jeong-Woo
Do Moon-Ho
Park Sang-Yong
Kim Sun-Yeou
Maeng Sung-Ho
Park Yoo-Kyoung
Park Ji-Ho
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Abstract
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Artemisia princeps (AP) is a flowering perennial used as a traditional medicine and dietary supplement across East Asia. No study has yet assessed its effects on synaptic plasticity in hippocampus and much less in a model of ovarian hormone deficiency. We examined the influence of chronic oral AP ethanol extract treatment in ovariectomized rats on the induction of long-term depression in a representative synapse (CA3-CA1) of the hippocampus. Ovariectomized rats demonstrated lower trabecular mean bone mineral densities than sham, validating the establishment of pathology. Against this background of pathology, AP-treated ovariectomized rats exhibited attenuated long-term depression (LTD) in CA1 relative to water-treated controls as measured by increased field excitatory post-synaptic potentials (fEPSP) activation averages over the post-stimulation period. While pathological significance of long-term depression (LTD) in ovariectomized rats is conflicting, that AP treatment significantly affected its induction offers justification for further study of its influences on plasticity and its related disorders.
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KEYWORD
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Artemisia princeps, Oriental medicine, ovariectomy, long-term depression (LTD), hippocampal synaptic plasticity
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